Oligomerization of fibroblast grow factor 2 at model plasma membranes: a single molecule fluorescence study

FGF2 is a protein that has numerous biological functions in living organisms including uncontrollable growth of tumours, wound healing and embryonic development. After being synthesized inside the cell, FGF2 is excreted into the extracellular space. Although the membrane plays an important role in the entire excretory process little is known about the interaction of FGF2 with the membrane. This work aims at elucidating in detail the mechanism by which FGF2 is translocated across the cellular plasma membrane.

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doc. RNDr. Šachl Radek Ph.D.

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