Chemometric characterization of voltammetric signals affected by adsorption

The project aims to expand the gain of information values ​​from performed voltammetric measurements, especially those influenced by adsorption and desorption processes. It will focus on the development and optimization of chemometric calculation modules for programs such as ETP and Excel, including the creation of programs for data conversion and their database archiving. Emphasis will be placed on the optimization of existing modules and the implementation of modern statistical tools.

The key task will be research into the analysis and characterization of voltammetric signals associated with adsorption and desorption processes using selected chemometric approaches (e.g. QP, QS-tests, statistical moments, Fourier analysis) and elimination voltammetry procedures. It will enable mathematical separation and combination of different types of currents (capacitive, faradaic, kinetic). The project also includes the creation and improvement of mathematical software for automated and objective evaluation of mixed calibration dependencies and electrocapillary measurements.

Other model and practically important substances (e.g. selected thiolates, DNA, petroleum substances, detergents) will be studied using hydrogen peroxide voltammetry and chemometric characterization of their voltammetric signals. The project will also include measurement of calibration dependences of surfactant mixtures and research into possible interferences and disturbing events and their connection with chemometric analysis of adsorption processes.

Practical applications will focus on elucidating the processes on the surface of a mercury drop electrode during hydrogen peroxide reduction influenced by the presence of PAL. Furthermore, there will be chemometric evaluation of data obtained during the analysis of body fluids of patients exposed to lead or other contaminants, with the aim of simplifying the characterization of the degree of poisoning of the organism, and research into metal complexes to clarify the stoichiometry and kinetics of formation.

The project will also deal with the development of new electrodes and the application of chemometric procedures for the determination of thiodiglycolic acid in urine.