Electron transfer in bioactive compounds and drugs

New psychoactive substances

New psychoactive substances (NPS) are investigated. Since the electron transfer is a part
of bioactivity or metabolism in organisms, the knowledge of a redox properties
can help to understand their activity, determination of the reaction scheme, the first reaction intermediates and final products.

 publications   2020-2024

Reduction of substituted derivatives of salicylic acid

Drug diflunisal, a synthetic difluorophenyl derivative of salicylic acid, belongs to the
nonsteroidal anti-inflammatory drug class (NSAID). Since the electron transfer is a part
of bioactivity or metabolism in organisms, the knowledge of a reductive degradation of drugs
is required.
 publications   2014-2016

Radiosensitizers, magnetic resonance contrast agents

1/ Radiosensitizers are drugs that make cancer cells more sensitive to radiation therapy.
Eight nitrocompounds as metronidazole were chosen for electrochemical investigation and their futile reduction under aerobic conditions was studied.
2/ The electrochemical behaviour of europium complexes of potential MR imaging ligands was studied using several electrochemical methods. Agents as DTPA, DOTA, as well as newly developed ligands were used for complexation.
 publications   2011-2016


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