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Self-assembled porphyrin systems
The rapid self-assembly
of highly ordered linear, two- and three-dimensional
molecular structures from small components could
play a central role in the future fabrication of
nanoscale devices and molecular machinery. Self-assembly
greatly reduces the cost of synthesis of
multiporphyrin or multichromophoric systems by
increasing the yields sometimes by several
orders of magnitude compared to the equivalent
covalent arrays – if the latter are
synthetically accessible at all. Combinations of
chromophores may yield materials with properties
unobtainable with single component systems. The
knowledge of binding modes of porphyrin
aggregates and their control by peripheral
substituents and/or insertion of metals are
bases for design nanoelectronic and
supramolecular chemical devices such molecular
memories, sensitive/selective probes for
molecular recognition and biodiagnostics,
special surfaces with catalytic/antiviral
activity and porphyrin nanodevices for
photocatalytic solar hydrogen production.
Experiments with templates could also contribute
to the search of the new carriers for transport
of porphyrin-type drugs that are used to the
combating cancer by photodynamic therapy.
Photodisinfection materials based on porphyrin
derivatives
Incorporation
into solid matrices increases the chemical and
photochemical stability of the photoactive
compounds.Growing emergence of antibiotic
resistance amongst pathogenic bacteria has led
to a major research effort to find alternative
antibacterial therapeutics to which bacteria
will not easily develop resistance. This
approach stemming from a pool of rational
chemical and physicochemical information
represents promising areas of research in
medical inorganic chemistry with a great
potential for photodynamic inactivation of
bacteria. In this context some SOM are expected
to be effective photodisinfecting materials even
under daylight. Some porphyrin-based silicate
materials are also expected to find application
in the process of controlling and probing
enzymatic reactions in bioreactors.
Photophysics of
porphyrin derivatives and other
photosensitizers
Basic methods
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UV/VIS/near infrared spectrometry
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Steady-state and time-resolved fluorescence spectroscopy
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Laser flash photolysis with excimer and dye lasers
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Optoacoustic spectroscopy
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FTIR spectroscopy
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Atomic force microscopy
References
Kubát P., Lang K.,
Cígler P., Kožíšek M., Matějíček P.,
Janda P., Zelinger Z., Procházka K., Král
V.: Tetraphenylporphyrin-cobalt(III) bis(1,2-dicarbollide)
conjugates: from the solution characteristics to inhibition of
HIV protease. J.Phys.Chem. B 111, 4539 – 4546 (2007).
Click
for abstract
Mosinger J., Jirsák
O., Kubát P., Lang K., Mosinger B. Jr.: Bactericidal
nanofabrics based on photosensitized formation of singlet
oxygen. J .Mater. Chem.
17,
164 – 166 (2007).
Click for abstract
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