TOPIC: Molecular Electrocatalysis.
Metalloprotein photoactivation: Structural dynamics and electron transfer
LH13015 (KONTAKT), Ministry of Education, Youth and Sports of the Czech Republic
This project aims to find and understand new mechanisms and means of controlling long-range electron transfer in protein systems, relevant to development of fotocatalytic systems for artificial photosynthesis, photoenzymes, and protein-based electronic/photonic devices. In addition, new functional model systems based on azurin and cytochrome mutants will be designed, synthesized, and characterized. Specifically, the project will concentrate on three areas: i) acceleration of long-range electron transfer by electron-hopping through intervening tryptophan residues in Pseudomonas aeruginosa azurin mutants, ii) coupling between electron-transfer and structural relaxation dynamics in azurins and cytochromes, and, iii) development, synthesis and characterization of new chromophores triggering electron-transfer in biomolecules and of new functional protein-based systems.
prof. RNDr. VLÄŚEK AntonĂn, CSc.
Department: Department of Biophysical Chemistry
Phone: (+420) 26605 2093
Fax: (+420) 286582307